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Mean reductions from baseline in daily antacid dose were statistically significant for all Aciphex groups when compared to placebo at both Weeks 4 and 8 (p≤0. Normalization of 24-hour intraesophageal acid exposure was correlated to gastric pH>4 for at least 35% of the 24-hour period; this level was achieved in 90% of subjects receiving Aciphex 20 mg and in 100% of subjects receiving Aciphex 40 mg. The only exception was the Aciphex 40 mg group versus placebo at Week 2 for duodenal ulcer pain frequency (p=0. Some patients with Zollinger-Ellison syndrome have been treated continuously with Aciphex for up to one year. Aciphex 20 mg inhibits basal and peptone meal-stimulated acid secretion versus placebo by 86% and 95%, respectively, and increases the percent of a 24-hour period that the gastric pH>3 from 10% to 65% (see table below).
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